Publications

Jose I. Lopez, Rafael Pulido, Jesus M. Cortes , Javier C. Angulo, and Charles H. Lawrie. Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy.  Pathol Res Pract 214:1110-1114, 2018 [pdf] Abstract Intratumor heterogeneity (ITH) detection remains a challenge in modern oncology because it can have a direct impact on the success of new therapies. Anti-PD-1/PD-L1 immunotherapy is an emerging treatment modality that is showing great promise for […]

Javier Rasero, Ibai Diez, Jesus M Cortes, Daniele Marinazzo and Sebastiano Stramaglia. Connectome sorting by Consensus Clustering increases separability in group neuroimaging studies. Network Neuroscience , 3: 325–343, 2018 [pdf] Abstract A fundamental challenge in preprocessing pipelines for neuroimaging datasets is to increase the signal-to-noise ratio for subsequent analyses. In the same line, we suggest here that the application of the consensus clustering approach to brain connectivity matrices can be […]

Javier Rasero, Hannelore Aerts, Marlis Ontivero Ortega, Jesus M. Cortes, Sebastiano Stramaglia , Daniele Marinazzo. Predicting functional networks from region connectivity profiles in task-based versus resting-state fMRI data PLoS One, 13: e0207385, 2018 [pdf] Abstract Intrinsic Connectivity Networks, patterns of correlated activity emerging from “resting-state” BOLD time series, are increasingly being associated with cognitive, clinical, and behavioral aspects, and compared with patterns of activity elicited by specific tasks. We study […]

Iñigo Gabilondo, Verónica Llorens, Trinidad Rodriguez, Manuel Fernández, Tomas Pérez Concha, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocío del Pino, Jesús Cortés, Juan Carlos Gómez-Esteban. Myocardial MIBG scintigraphy in genetic Parkinson’s disease as a model for Lewy body disorders. European Journal of Nuclear Medicine and Molecular Imaging, 46:376-384, 2019 [pdf] Purpose. To identify myocardial sympathetic denervation patterns suggestive of Lewy body (LB) pathology in patients with genetic and idiopathic parkinsonisms […]

Borja Camino-Pontes, Ibai Diez, Antonio Jimenez-Marin, Javier Rasero, Asier Erramuzpe, Paolo Bonifazi, Sebastiano Stramaglia, Stephan Swinnen and Jesus M. Cortes. Interaction Information Along Lifespan of the Resting Brain Dynamics Reveals a Major Redundant Role of the Default Mode Network. Entropy 20: 742, 2018 [pdf] Abstract Interaction Information (II) generalizes the univariate Shannon entropy to triplets of variables, allowing the detection of redundant (R) or synergetic (S) interactions in dynamical networks. […]

Olaia Aurtenetxe, Laura Zaldumbide, Asier erramuzpe, Ricardo Lpez, Jos I Lopez, Jess M Cortes, Rafael Pulido* and Caroline E Nunes-Xavier*. (*Equal last-author contribution). DUSP5 expression associates with poor prognosis in human neuroblastoma. Experimental and Molecular Pathology, 105:272-278, 2018 [pdf] Abstract Regulation of growth and differentiation of neuroblastoma (NB) cells is the rational of some maintenance therapies for high-risk NB. MAP kinase phosphatases (MKPs) are potential physiologic regulators of neuronal differentiation […]

Paolo Bonifazi, Asier Erramuzpe, Ibai Diez, Iñigo Gabilondo, Matthieu P. Boisgontier, Lisa Pauwels, Sebastiano Stramaglia, Stephan P. Swinnen and Jesus M. Cortes. Structure–function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging. Human Brain Mapping, 39: 4663–4677, 2018 [pdf] Abstract Physiological aging affects brain structure and function impacting morphology, connectivity, and performance. However, whether some brain connectivity metrics might reflect the age of an individual is […]

T. Lissek., et. al. , M.T. Hasan. Building Bridges through Science. Neuron 96:730-735, 2017 [pdf] Science is ideally suited to connect people from different cultures and thereby foster mutual understanding. To promote international life science collaboration, we have launched ‘‘The Science Bridge’’ initiative. Our current project focuses on partnership between Western and Middle Eastern neuroscience communities.

A. Erramuzpe, JM Cortes and JI Lopez. Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor evolution. Virchows Arch 472:187-194, 2018 [pdf] Abstract Intratumor heterogeneity (ITH) is an inherent process of tumor development that has received much attention in previous years, as it has become a major obstacle for the success of targeted therapies. ITH is also temporally unpredictable across tumor evolution, which […]

Javier Rasero*, Carmen Alonso Montes*, Ibai Diez*, Laiene Olabarrieta-Landa, Lakhdar Remaki, Iñaki Escudero, Beatriz Mateos Goñi, Paolo Bonifazi, Manuel Fernandez Martinez, Juan Carlos Arango-Lasprilla, Sebastiano Stramaglia** and Jesus Cortes** (*Equal first-author contribution) (**Equal last-author contribution). Group-Level Progressive Alterations in Brain Connectivity Patterns Revealed by Diffusion-Tensor Brain Networks across Severity Stages in Alzheimer’s Disease. Frontiers in Aging Neuroscience 9:215, 2017 [pdf] Alzheimer’s disease (AD) is a chronically progressive neurodegenerative disease highly […]

J Rasero, M Pellicoro, L Angellini, JM Cortes, D Marinazzo, S Stramaglia. Consensus clustering approach to group brain connectivity matrices. Network Neuroscience 1: 242-253, 2017 [pdf] A novel approach rooted on the notion of consensus clustering, a strategy developed for community detection in complex networks, is proposed to cope with the heterogeneity that characterizes connectivity matrices in health and disease. The method can be summarized as follows: (i) define, for […]

JM Cortes, Giovanni de Petris, JI Lopez. Detection of intra-tumor heterogeneity in modern pathology: A multi-site tumor sampling (MSTS) perspective. Frontiers in Medicine 4:25 , 2017 [pdf] Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is […]

JM Kroos, I Marinelli, I Diez, JM Cortes, S Stramaglia, and L Gerardo-Giorda. Patient-specific computational modeling of Cortical Spreading Depression via Diffusion Tensor Imaging. International Journal for Numerical Methods in Biomedical Engineering, 2017 [pdf] Cortical spreading depression, a depolarization wave originating in the visual cortex and traveling towards the frontal lobe, is commonly accepted as a correlate of migraine visual aura. As of today, little is known about the mechanisms […]

S. Stramaglia, M. Pellicoro, L. Angelini, E. Amico, H. Aerts, J.M. Cortes, S. Laureys, and D. Marinazzo. Ising Model with conserved magnetization on the Human Connectome: implications on the relation structure-function in wakefulness and anesthesia. Chaos 27: 047407, 2017 [pdf] Dynamical models implemented on the large scale architecture of the human brain may shed light on how function arises from the underlying structure.This is the case notably for simple abstract […]

Jose Ignacio Lopez and Jesus M Cortes. Multi-Site Tumor Sampling (MSTS): A new tumor selection method to enhance intratumor heterogeneity detection. Human Pathology 64:1-6, 2017 [pdf] Intratumor heterogeneity (ITH) is increasingly being recognized as a highly complex process with high clinical impact that deserves special attention from practicing pathologists. The goodness of the ITH detection depends on the correctness of the pathologist’s sampling. The goal of this review is twofold. […]

Ildefonso de la Fuente, Iker Malaina, Alberto Perez-Samartin, Maria D. Boyano, Gorka Perez- Yarza, Carlos Bringas, Alvaro Villarroel, Maria Fedetz, Jesus M Cortes and Luis Martinez. Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes. Scientific Reports 7:41791, 2017 [pdf] Chloride is the most abundant permeable anion in the cell, and numerous studies in the last two decades highlight the great importance and broad physiological role of chloride currents […]

Jose Ignacio Lopez, Asier Erramuzpe, Rosa Guarch, Jesus M Cortes, Roberto Llarena and Javier C Angulo. CD34 immunostaining enhances a distinct pattern of intratumor angiogenesis with prognostic implications in clear cell renal cell carcinoma. APMIS 125: 128-133, 2017 [pdf] Clear cell renal cell carcinoma is an aggressive neoplasm related to VHL gene inactivation. The molecular events derived from this initial alteration lead to a permanent intracellular pseudo-hypoxic status that stimulates […]

Ibai Diez, David Drijkoningen, Sebastiano Stragmalia, Paolo Bonifazi, Daniele Marinazzo, Jolien Gooijers, Stephan P. Swinnen, Jesus M. Cortes. Enhanced pre-frontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population. Network Neuroscience 1: 116-142, 2017 [pdf] Preprint at [pdf] Traumatic brain injury (TBI) affects the structural connectivity, triggering the re-organization of structural-functional circuits in a manner that remains poorly understood. We focus here on brain […]

J Mingo, A Erramuzpe, S Luna, I Diez, JM Cortes and R Pulido. One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections. PLoS One 11: e0160972, 2016 [pdf] Site-directed mutagenesis (SDM) is a powerful tool to create defined collections of protein variants for experimental and clinical purposes, but effectiveness is compromised when a large number of mutations is required. We present here a one-tube-only standardized SDM […]

Lopez JI and Cortes JM. A multi-site cutting device implements efficiently the divide-and-conquer strategy in tumor sampling. F1000Research 5:1587, 2016 [pdf] We recently showed that in order to detect intra-tumor heterogeneity a Divide-and-Conquer (DAC) strategy of tumor sampling outperforms current routine protocols. This paper is a continuation of this work, but here we focus on DAC implementation in the Pathology Laboratory. In particular, we describe a new simple method that […]

Guarch R, Cortes JM, Lawrie CH and Lopez JI. Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC). F1000Research 5: 2020, 2016 [pdf] Current standard-of-care tumor sampling protocols for CCRCC (and other cancers) are not efficient at detecting intratumoural heterogeneity (ITH). We have demonstrated that an alternative protocol, multi-site tumor in silico sampling (MSTS) based upon the divide and […]

Vitronectin and Dermcidin serum levels predict the metastatic progression of AJCC I-II early stage melanoma. Idoia Ortega-Martínez, Jesús Gardeazabal, Asier Erramuzpe, Ana Sanchez-Diez,Jesús M Cortés, María D. García-Vázquez, Gorka Pérez-Yarza, Rosa Izu, Jose Luís Díaz-Ramón, Ildefonso M. de la Fuente, Aintzane Asumendi and María D. Boyano. Int J Cancer 139:1598-607, 2016 [pdf] Like many cancers, an early diagnosis of melanoma is fundamental to ensure a good prognosis, although an important […]

S. Stramaglia, L. Angelini, G. Wu, J.M. Cortes, L. Faes and D. Marinazzo. Synergetic and redundant information flow detected by unnormalized Granger causality: application to resting state fMRI. IEEE Trans Biomed Eng 63: 2518 – 2524, 2016 [pdf] Abstract—Objectives We develop a framework for the analysis of synergy and redundancy in the pattern of information flow between subsystems of a complex network. Methods The presence of redundancy and/or synergy in […]

A divide-and-conquer strategy in tumor sampling enhances detection of intratumor heterogeneity in routine pathology: A modeling approach in clear cell renal cell carcinoma. JI Lopez and JM Cortes. F1000Research 5:385, 2016 [pdf] Intratumor heterogeneity (ITH) is an inherent process in cancer development which follows for most of the cases a branched pattern of evolution, with different cell clones evolving independently in space and time across different areas of the same […]

López JI, Errarte P, Erramuzpe A, Guarch R, Cortés JM, Angulo JC, Pulido R, Irazusta J, Llarena R, Larrinaga G. Fibroblast activation protein predicts prognosis in clear cell renal cell carcinoma. Hum Pathol. 54:100-105, 2016 [pdf] Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis […]

L.Zaldumbide, A. Erramuzpe, R. Guarch, R.l Pulido, J.M. Cortes and J.I. Lopez. Snail heterogeneity in clear cell renal cell carcinoma. BMC Cancer 16:194, 2016 [pdf] Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, leaving out of histological analysis foci of high grade tumor areas. Although molecular approaches are providing […]

S. Rodrigues, M. Desroches, M. Krupa, J.M. Cortes, T.J. Sejnowski and A.B. Ali. Time-coded neurotransmitter release at excitatory and inhibitory synapses. Proc Natl Acad Sci USA  113:E1108-15, 2016   [pdf] Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released […]