PhD | Physicist, Computer Scientist and Neuroscientist
PhD | Physicist, Computer Scientist and Neuroscientist

Potential impact of PD- L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherap

Jose I. Lopez, Rafael Pulido, Jesus M. Cortes , Javier C. Angulo, and Charles H. Lawrie. Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy.  Pathol Res Pract 214:1110-1114, 2018 [pdf]
Abstract
Intratumor heterogeneity (ITH) detection remains a challenge in modern oncology because it can have a direct impact on the success of new therapies. Anti-PD-1/PD-L1 immunotherapy is an emerging treatment modality that is showing great promise for clear cell renal cell carcinoma (CCRCC) patients with advanced disease. Patient selection for such therapy relies upon the immunohistochemical detection of PD-1/PD-L1, however the degree of ITH for these markers among tumor cells and/or inflammatory mononuclear infiltrates remains unknown. Therefore, we analyzed PD-L1 (SP-142) expression in the tumor inflammatory cells of 22 CCRCC cases with the aim to define the pattern of PD-L1 expression, and to compare the reliability of current tumor sampling protocols (RS) with a multisite tumor sampling strategy (MSTS). While the RS protocol identified 5/22 (22.7%) of cases that were positive for PD-L1 expression, MSTS identified 10/22 (45.45%) of cases. This suggests that RS may miss a proportion of CCRCC patients that might benefit from immunotherapy. In addition, MSTS demonstrated that positive and negative regions of PD-L1 expression are very variable within each tumor.

This website uses its own cookies for its proper functioning and better user experience. By navigating this website and/or clicking the Accept button, you agree to the use of these technologies and the processing of your data for these purposes. More information    Privacy policy
Privacidad