Li Lihong, Zhang Peiyun, Chen Xingyu, Han Lu, Liang Fengling, Jesús M. Cortés. Clinical Efficacy of Acupuncture in the Treatment of Adolescent Depression and Its Mechanism Revealed by Functional Magnetic Resonance Imaging and Serum Proteomics: A Multicenter, Double-Blind, Randomized Controlled Trial. Journal of Traditional Chinese Medicine 67:1858–1867, 2026 [pdf] Abstract Objective: To evaluate the clinical efficacy of acupuncture in the treatment of adolescent depression and to explore its potential mechanisms […]
XIE Zhongxuan, XU Zitong, JIN Wei, Jesús M. Cortés, LI Lihong. Bibliometric analysis of research hotspots and trends on Parkinson’s disease with excessive daytime sleepiness based on Web of Science database. J.Math.Med. 39 (7), 2026 [pdf] Abstract Objective: To conduct a bibliometric and visualization analysis of the literature on Parkinson’s disease with excessive daytime sleepiness, identifying research hotspots and development trends. Methods: Literature on Parkinson’s disease with excessive daytime sleepiness […]
Nooshin Safari, Isaac Levy, Aiying Zhang, Chirag Agarwal, Jesus M Cortes, Kevin A Pelphrey, John Darrell Van Horn, Javier Rasero. Brain morphology network profiles in male and female youth with autism. Cerebral Cortex 36, Issue 9, September 2026, bhag156 [pdf] Neuroimaging studies based on altered functional and structural connectivity have contributed to better characterizing males and females with Autism Spectrum Disorder (ASD), advancing our understanding of the male prevalence in […]
J.E. Arco, R. Alizadehsani, M. Atzmueller, E. Barakova, L. Bloch, G. Bologna, P. Bonomini, S.-B. Cho, J.M. Cortes, A. Elazab, M.A. Khan, E. Domínguez, R.J. Duro, A. Fernández-Caballero, E. Fernández-Jover, J.M. Ferrández-Vicente, Christoph M. Friedrich, J. García-Rodríguez, J. Garrigós, A. Gómez-Rodellar, P. Gómez-Vilda, M. Graña, A. Hernández, Yujing Huang, C. Jiménez-Mesa, J. Levin, N. Liu, Q. Ma, F.J. Martínez-Murcia, R. Martínez-Tomás, J.M. Molina, G.J. Nalepa, A. Ortiz, D. Palacios-Alonso, M. […]
Claudia Aponte, Antonio Jimenez-Marín, Malen Razkin, John Fredy Ochoa Gómez, Asier Erramuzpe, Ibai Diez, David Aguillón-Niño, Carlos Tobón, Jesús M. Cortés. Subregional Functional Connectivity of the Precuneus as a Preclinical Biomarker in Alzheimer’s Disease. Neurology Research International, 7281786, 2026 [pdf] Abstract Introduction: The precuneus(Pc)isacentralhubintegratingdiversebrainfunctions,anditisearlyinvolvedinAlzheimer’s disease (AD)pathophysiology,yetitssubregionalvulnerabilityremainspoorlyunderstood.Thisstudyaimstodelineatethe diBerential involvementandvulnerabilityofthesesubdivisionsintheearlystagesofAD. Methods: We conductedaresting-stateFCanalysisofPcsubregionsin32cognitivelyunimpairedcarriersofthePSEN1E280A mutation comparedto25noncarriersusingseed-basedanalyses. Results: As comparedtononcarriers,wefoundthatthegroupofasymptoticcarriershadincreasedconnectivityfromthe7Am subregion towardtheentorhinalcortex,superiortemporalgyrus,insula-operculum,dlPFC,andsomatosensoryareas.Moreover, the POS2subregionsigniFcantlydecreasedconnectivitywiththeanteriorinsulaanddlPFC.HigherMoCAscorescorrelatedwith increased connectivitywithinandbetweenthePcandfrontoparietalnetworks. Discussion: These resultsrevealdistinctpatternsofearlyfunctionalreorganizationandsupportthesubregionalPcanalysisin identifying sensitivebiomarkersforpreclinicalAD,oftenoverlookedinconventionalwhole-regionanalyses.
Izaro Fernandez-Iriondo, Antonio Jimenez-Marin, Naiara Aginako, Gorka Zamora-López, Asier Erramuzpe, Paolo Bonifazi, and Jesus M. Cortes. Modular structure-function coupling reveals different network reorganization for task performance. Communications Biology, In press, 2026 [pdf] Understanding how structural and functional brain networks interact to support cognition remains a central challenge in systems neuroscience. Here, we investigated modular structure–function coupling (SFC) across cognitive tasks using multimodal neuroimaging data. We separated SFC into intra-modular coupling […]
Mónica Otero, Felipe I. Carriel-Rubilar, Hernan Hernandez, Jhosmary Cuadros, Jorge G. Condado, Agustin Sainz-Ballesteros, Hernando Santamaria-Garcia, Agustina Legaz, Agustina Birba, Sol Fittipaldi, Francisco Lopera, John Ochoa-Gómez, David Aguillon, Alfredis González-Hernández, Jasmin Bonilla-Santos, Rodrigo A. Gonzalez-Montealegre, Görsev G. Yener, Bahar Güntekin, İlayda Kıyı, Tuba Aktürk, Ebru Yıldırım, Lütfü Hanoğlu, Renato Anghinah, Pedro A. Valdes-Sosa, Ronaldo Garcia-Reyes, Javier Escudero, Susanna Lopez, Robert Whelan, Alberto Fernández, Adolfo M. García, David Huepe, Marcio Soto-Añari, […]
Jorge Garcia Condado, Hannah M Klinger, Colin Birkenbihl, I˜nigo Tellaetxe Elorriaga, Mabel Seto, Gillian T Coughlan, Michael J. Properzi, Hyun-Sik Yang, Asier Erramuzpe, Dorene M. Rentz, Aaron P. Schultz, Jasmeer P. Chhatwal, Keith A. Johnson, Jesus M Cortes, Reisa A. Sperling, Timothy J. Hohman, Michael C. Donohue, Ibai Diez, Rachel F. Buckley. BrainAge moderates associations between AD biomarkers and cognitive decline: findings from A4/LEARN and the Harvard Aging Brain Study. […]
Felipe A. Torres, Alejandro Weinstein, Jesus M. Cortes, Wael El-Deredy. Intrinsic resonance depends on network size for coupled-delayed interacting oscillators. Physical Review E. In press, 2026 [pdf] arXiv: [2511.14065v1] The collective frequency that emerges from synchronized neuronal populations—the network resonance— shows a systematic relationship with brain size: a whole-brain large network oscillates slowly, whereas finer parcellations of fixed volume exhibit faster rhythms. This resonance–size scaling has been reported in delayed […]
I. Diez, F. Garcia-Moreno, N. Carral-Sainz, S. Stramaglia, A. Nieto-Reyes, M. D’Amato, J.M. Cortes, P. Bonifazi. Connectivity of the adult human brain with sequential neurogenesis of circuits and transcriptomics signatures. Nat Comm. In press, 2026 [pdf] bioRxiv: [2022.04.01.48654] Understanding the architectural principles that shape human brain networks is a major challenge for systems neuroscience. We hypothesize that the centrality of the different brain circuits in the human connectome is a […]
Conectividad cerebral, ciencia de datos y Neuropsicología. Facultad de Ciencias de la Rehabilitación y Calidad de Vida. Universidad de San Sebastian, Santiago, Chile. March 23th, 2026
Brain networks and physiological interactions in the healthy and the pathological brain. Escuela de Ingeniería, Universidad de Concepcion, Chile. March 17th, 2026
Dys-connectivity of brain networks in post-stroke spasticity. II JORNADA DE TRASTORNS DEL MOVIMENT EN PACIENTS POST ICTUS: DECISIONS I ESTRATÈGIES PER LA PRÀCTICA ASSISTENCIAL. Clinic Univervesity, Barcelona, Spain. February 20th, 2026
The Data-Driven Brain: From Connectivity to Digital Neuropsychology. Academic Forum on Cognitive Assessment and Rehabilitation Based on Digital Neuropsychological Technology. Zhejiang Chinese Medical University. October 23th, Zhejiang, China
Data-driven innovation in digital neuropsychology. VI Congreso Iberoamericano de Neuropsicología. 16-18 Octubre, Quito, Ecuador
Conectividad cerebral, ciencia de datos y Neuropsicología. VI Congreso Iberoamericano de Neuropsicología. 16-18 Octubre, Quito, Ecuador
Impacto de la IA en la evaluacion cognitiva. Jornada Técnica Hermanas Hospitalarias: Presente y futuro de la evaluación neuropsicológica. Universidad Europea del Atlántico. Santander. 8 de Octubre, 2025
Jorge Garcia Condado, Ines Verdugo Recuero, Iñigo Tellaetxe Elorriaga, Colin Birkhenbil, Maria Carrigan, Ibai Diez, Rachel F Buckley, Asier Erramuzpe, Jesus M Cortes. Aging as an active player in Alzheimer’s Disease Classification: Insights from feature selection in BrainAge Models. Neuroimage 2025. [pdf] Abstract: Background: BrainAge models estimate the biological age of the brain using neuroimaging or clinical features, making them promising tools for studying neurodegenerative diseases like Alzheimer’s disease. However, […]
Francesca Santucci, Antonio Jimenez-Marin, Andrea Gabrielli, Paolo Bonifazi, Miguel Ibáñez-Berganza, Tommaso Gili, and Jesus M. Cortes.Partial correlation as a tool for mapping functional-structural correspondence in human brain connectivity. Network Neuroscience 2025. [pdf] Abstract: Brain structure-function coupling has been studied in health and disease by many different researchers in recent years. Most of the studies have estimated functional connectivity matrices as correlation coefficients between different brain areas, despite well-known disadvantages compared […]
Clara Inesta, Beatriz Bonete-Lopez, Javier Oltra-Cucarella, Borja Camino-Pontes, Jesus M. Cortes, Juan Carlos Arango-Lasprilla, Esther Sitges-Macia. Does engagement in cognitive activities contribute to the preservation of brain structure and connectivity in older adults?. Journal of the Neurological Sciences 477: 123658, 2025 [pdf] Abstract Aging is associated with changes in brain structure and connectivity and decrements in certain cognitive abilities. The benefits of active lifestyles in the aging brain and cognition […]
Brain structure and functional high order interactions in the human brain. Workshop on Information Theory in Computational Neuroscience. CNS*2025, Florence, Italy · July 9th, 2025
Neuroimagen y espectro autista: Avances en conectividad funcional. Primer congreso Iberoamericano sobre Avances en el Diagnóstico y Tratamiento del Espectro Autista. April 26th, 2025
Neuroimagen y espectro autista: Avances en conectividad funcional. Scientific Presentations in Neuroscience (SPIN). University of Granada, Spain. April 25th, 2025
Desconexión de redes cerebrales en la espasticidad después del ictus. TALLER TEÓRICO PRÁCTICO DE ESPASTICIDAD PARA EXPERTOS. Hosppital Universitario Gorliz. March 7th, 2025
Masterclass: Avances de conectividad cerebral en estudios clínicos. Máster en Neurociencia e Investigación en Imagen Neurológica Universidad Internacional de Valencia – VIU. February 13th, 2025
Fundamentos de la computación de la imagen. Neuroimagen computacional: Fundamentos en entorno intrahospitalario. Tecnología Médica aplicada en diagnóstico y terapia. Neuroimagen y Neurotecnología. Escuela de Ingeniería de Bilbao. November 12-14, 2024
Geraldine Rodríguez-Nieto, Caroline Seer, Hamed Zivari Adab, Antonio Jiménez-Marín, Sima Chalavi, Amirhossein Rasooli, Jesus M. Cortes, Stefan Sunaert, Stephan P. Swinnen. Efficiency of Structural Brain Networks Mediates Age-Associated Differences in Executive Functioning in Older Adults. Frontiers in Aging Neuroscience, 2025. [pdf] Abstract Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for […]
Changchun He, Jesus M. Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan. Brain Imaging and Behavior, 2025. [pdf] Abstract Accumulating neuroimaging evidence suggests that abnormal functional and structural brain connectivity plays a cardinal role in the pathophysiology of autism spectrum disorder (ASD). Here, we constructed brain networks of functional, structural, and morphological connectivity using data from functional magnetic resonance imaging (fMRI), diffusion tensor […]
Marlis Ontivero-Ortega, Luca Faes, Jesus M. Cortes, Daniele Marinazzo, and Sebastiano Stramaglia. Assessing high-order effects in feature importance via predictability decomposition. Physical Review 111: L033301, 2025. [pdf] Abstract Building on recent advances in describing redundancy and synergy in multivariate interactions among random variables, we propose an approach to quantify cooperative effects in feature importance, a key technique in explainable artificial intelligence. Specifically, we introduce an adaptive version of the widely […]