Geraldine Rodríguez-Nieto, Caroline Seer, Hamed Zivari Adab, Antonio Jiménez-Marín, Sima Chalavi, Amirhossein Rasooli, Jesus M. Cortes, Stefan Sunaert, Stephan P. Swinnen. Efficiency of Structural Brain Networks Mediates Age-Associated Differences in Executive Functioning in Older Adults. Frontiers in Aging Neuroscience, 2025. [pdf] Abstract Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for […]

Changchun He, Jesus M. Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan. Brain Imaging and Behavior, 2025. [pdf] Abstract Accumulating neuroimaging evidence suggests that abnormal functional and structural brain connectivity plays a cardinal role in the pathophysiology of autism spectrum disorder (ASD). Here, we constructed brain networks of functional, structural, and morphological connectivity using data from functional magnetic resonance imaging (fMRI), diffusion tensor […]

Marlis Ontivero-Ortega, Luca Faes, Jesus M. Cortes, Daniele Marinazzo, and Sebastiano Stramaglia. Assessing high-order effects in feature importance via predictability decomposition. Physical Review 111: L033301, 2025. [pdf] Abstract Building on recent advances in describing redundancy and synergy in multivariate interactions among random variables, we propose an approach to quantify cooperative effects in feature importance, a key technique in explainable artificial intelligence. Specifically, we introduce an adaptive version of the widely […]

Asier Erramuzpe, Ane Murueta-Goyena, Antonio Jimenez-Marin, Marian Acera, Sara Teijeira-Portas, Rocío Del Pino, Tamara Fernández-Valle, Ibai Diez, Unai Sainz-Lugarezaresti, Naroa Ibarretxe-Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera-Zubizarreta, Jesús Cortés, Juan Carlos Gómez-Esteban, Iñigo Gabilondo. Amygdala Neurodegeneration: A Key Driver of VisualDysfunction in Parkinson’s Disease. Ann Clin Transl Neurol 12: 768-779, 2025. [pdf] Abstract Objective: Visual disability in Parkinson’s disease (PD) is not fully explained by retinal neurodegeneration. We aimed to […]

Jorge Garcia Condado, Iñigo Tellaetxe-Elorriaga, Jesus M. Cortes, and Asier Erramuzpe. AgeML: Age Modeling With Machine Learning. IEEE Journal of Biomedical and Health Informatics: 29, 3772-3781, 2025. [pdf] Abstract An approach to age modeling involves the supervised prediction of age using machine learning from subject features. The derived age metrics are used to study the relationship between healthy and pathological aging in multiple body systems, as well as the interactions […]

Joana Garmendia, Garazi Labayru, Antonio Jiménez-Marín, Jorge Villanúa, Jesús Cortés, Adolfo López de Munain and Andone Sistiaga. Hyperconnectivity in resting-state fMRI as a marker of disease severity in Myotonic Dystrophy Type 1. J Neuromuscul Dis 2025; 12: 90–101. [pdf] Abstract Introduction: Myotonic dystrophy type 1 (DM1) patients show both structural and functional brain alterations, including abnormal resting-state (RS) functional connectivity. Although some studies have investigated RS functional connectivity in DM1, […]

Sebastiano Stramaglia, Luca Faes, Jesus M. Cortes, and Daniele Marinazzo. Disentangling high-order effects in the transfer entropy. Phys Rev Res 6, L032007 (2024). [pdf] Abstract Transfer entropy (TE), the primary method for determining directed information flow within a network system, can exhibit bias—either in deficiency or excess—during both pairwise and conditioned calculations, owing to high-order dependencies among the dynamic processes under consideration and the remaining processes in the system used […]

Ildefonso M. De la Fuente, Jose Carrasco-Pujante, Borja Camino-Pontes, Maria Fedetze, Carlos Bringas, Alberto Pérez-Samartín, Gorka Pérez-Yarza, José I. López, Iker Malaina, and Jesus M. Cortes. Systemic cellular migration: The forces driving the directed locomotion movement of cells. PNAS nexus. In press, 2024. [pdf] Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements […]

Antonio Jimenez-Marin, Ibai Diez, Asier Erramuzpe, Sebastiano Stramaglia, Paolo Bonifazi, and Jesus M. Cortes. Open datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brain. Scientific Data. In press, 2024. [pdf] Abstract The human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connections is critical to advancing our […]

D Ramos-Usuga, A Jimenez-Marin, A Cabrera Zubizarreta, I Benito-Sanchez, D Rivera, E Martinez-Gutierrez, E Panera, V Boado, Fermin Labayen, J M Cortes, Juan C. Arango-Lasprilla. Cognitive and brain connectivity trajectories at one-year post intensive care unit discharge in individuals with COVID-19. Neurorehabilitation. In press, 2024. [pdf] Abstract BACKGROUND: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with […]