JCR Articles

Endika Martinez-Gutierrez, Antonio Jimenez-Marin, Sebastiano Stramaglia and Jesus M. Cortes. The structure of anticorrelated networks in the human brain.  Frontiers in Network Physiology, 2022 [pdf] During the performance of a specific task–or at rest–, the activity of different brain regions shares statistical dependencies that reflect functional connections. While these relationships have been studied intensely for positively correlated networks, considerably less attention has been paid to negatively correlated networks, a. k.a. […]

Marilyn Gatica, Fernando E. Rosas, Pedro A. M. Mediano, Ibai Diez, Stephan P. Swinnen, Patricio Orio, Rodrigo Cofre, Jesus M. Cortes. High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model.  PLoS Comput Biol 18(9): e1010431. [pdf] The human brain generates a rich repertoire of spatio-temporal activity patterns, which support a wide variety of motor and cognitive functions. These patterns of activity change with age […]

Martin Iniguez, Antonio Jimenez-Marin, Asier Erramuzpe, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocio Del Pino, Tamara Fernandez, Mar Carmona‑Abellan, Alberto Cabrera-Zubizarreta, Juan Carlos Gómez‑Esteban, Jesus M. Cortes and Inigo Gabilondo. Heart-brain synchronization breakdown in Parkinson’s disease.  npj Parkinson’s Disease (2022) 64 [pdf] Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed […]

Izaro Fernandez-Iriondo, Antonio Jimenez-Marín, Basilio Sierra, Naiara Aginako, Paolo Bonifazi, and Jesus M. Cortes. Brain mapping of behavioral domains using multi-scale networks and canonical correlation analysis. Front. Neurosci. 2022.  article: [pdf] Abstract Simultaneous mapping of multiple behavioral domains into brain networks remains a major challenge. Here, we shed some light on this problem by employing a combination of machine learning, structural and functional brain networks at different spatial resolutions (also […]

Garazi Labayru, Borja Camino, Antonio Jimenez‑Marin, JoanaGarmendia , JorgeVillanua , Miren Zulaica, Jesus M. Cortes, Adolfo López de Munain & Andone Sistiaga. Scientific Reports 12:3988, 2022  article: [pdf] Abstract Myotonic Dystrophy Type 1 (DM1) is a multisystemic disease that afects gray and white matter (WM) tissues. WM changes in DM1 include increased hyperintensities and altered tract integrity distributed in a widespread manner. However, the precise temporal and spatial progression of […]

Maider Nuñez-Ibero, Borja Camino-Pontes, Ibai Diez, Asier Erramuzpe, Endika Martinez-Gutierrez, Sebastiano Stramaglia, Javier O. Alvarez-Cienfuegos, and Jesus M. Cortes. A Controlled Thermoalgesic Stimulation Device for Exploring Novel Pain Perception Biomarkers. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 25: 2948-2957, 2021. biorxiv: [pdf] article: [pdf] Abstract Objective: To develop a new device for identifying physiological markers of pain perception by reading the brain’s electrical activity and hemodynamic interactions while applying thermoalgesic […]

Antonio Jimenez-Marin, Ibai Diez, Maria C. Caballero, Isidro Ferrer, Garazi Labayru, Pol Andres-Benito, Andone Sistiaga, Jorge Sepulcre, Adolfo Lopez de Munain, and Jesus M. Cortes. Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. Neuropathology and Applied Neurobiology . In press, 2021. biorxiv: [pdf] article: [pdf] Abstract Aim: To delineate the neurogenetic profiles of brain degeneration patterns in myotonic dystrophy type I (DM1). Methods: In two cohorts […]

Changchun He, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Huafu Chen, Jinming Xiao, Xiaolong Shan, Rui Feng, Xujun Duan. Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder. Human Brain Mapping. In press, 2021 [pdf] Abstract Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. […]

Leire Torices, Javier de las Heras, Juan Carlos Arango-Lasprilla, Jesús M. Cortes, Caroline E. Nunes-Xavier , Rafael Pulido. MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution. Molecular Genetics and Metabolism Reports. In press, 2021 [pdf] Abstract Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients […]

Sandra Luna, Leire Torices, Janire Mingo, Laura Amo, Isabel Rodríguez‐Escudero, Pablo Ruiz‐Ibarlucea, Asier Erramuzpe, Jesús M. Cortés, María I. Tejada, María Molina, Caroline E. Nunes‐Xavier, José I. López, Víctor J. Cid, and Rafael Pulido. A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons. Human Mutation. In press, 2021 [pdf] Abstract The PTEN tumor suppressor gene is mutated with high incidence in […]

Marilyn Gatica, Rodrigo Cofré, Pedro A.M. Mediano, Fernando E. Rosas, Patricio Orio, Ibai Diez, Stephan P. Swinnen, and Jesus M. Cortes. High-order interdependencies in the aging brain. Brain connectivity . In press, 2021. biorxiv: [pdf] article: [pdf] Abstract Background: Brain interdependencies can be studied from either a structural/anatomical perspective (“structural connectivity”-SC) or by considering statistical interdependencies (“functional connectivity”-FC). Interestingly, while SC is by definition pairwise (white-matter fibers project from one […]

JJ Torres, MA Muñoz, Jesus M Cortes, J Mejias. Special Issue on Emergent Effects in Stochastic Neural Networks with Application to Learning and Information Processing. Neurocomputing . In press, 2021. [pdf] Abstract This special issue includes a series of 12 articles, which represent a selection of extended contributions presented at the 15th Granada Seminar on Computational and Statistical Physics held in Granada from September 17 to 20, 2019, and organized […]

A Safari, P Moretti, I Diez, JM Cortes, MA Muñoz. Persistence of hierarchical network organization and emergent topologies in models of functional connectivity. Neurocomputing . In press, 2021. arxiv: [pdf] article: [pdf] Abstract Functional networks provide a topological description of activity patterns in the brain, as they stem from the propagation of neural activity on the anatomical or structural network of synaptic connections. This last is well known to be […]

I Fernandez-Iriondo, A Jimenez-Marin, I Diez, P Bonifazi, SP Swinnen, MA Munoz, JM Cortes. Low variability of dynamical functional connectivity in cerebellar networks. Neurocomputing . In press, 2021 biorxiv: [pdf] article: [pdf] Abstract Brain networks can be defined and explored using different types of connectivity. Here, we studied P=48 healthy participants with neuroimaging state-of-the-art techniques and analyzed the relationship between the actual structural connectivity (SC) networks (between 2514 regions of […]

Ane Murueta‐Goyena, Rocío Del Pino, Marta Galdós, Begoña Arana, Marian Acera, Mar Carmona‐Abellán, Tamara Fernández‐Valle, Beatriz Tijero, Olaia Lucas‐Jiménez, Natalia Ojeda, Naroa Ibarretxe‐Bilbao, Javier Peña, Jesus Cortes, Unai Ayala, Maitane Barrenechea, Juan Carlos Gómez‐Esteban, and Iñigo Gabilondo. Retinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Disease. Annals of neurology 89: 165-176, 2021 [pdf] Abstract Objective: This study was undertaken to analyze longitudinal changes of retinal thickness and their […]

Garazi Labayru, Antonio Jimenez-Marin, Esther Fernandez, Jorge Villanua, Miren Zulaica, Jesus M. Cortes, Ibai Diıez, Jorge Sepulcre, Adolfo Lopez de Munain, Andone Sistiaga. Neurodegeneration trajectory in pediatric and adult/lateDM1: A follow-up MRI study across a decade. Annals of Clinical and Translational Neurology 7:1802-1815, 2020 [pdf] Abstract Objective: To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential […]

Javier De Las Heras, Ibai Diez, Antonio Jimenez-Marin, Alberto Cabrera, Daniela Ramos-Usuga, Marta Venecia Diaz-Fernandez, Leire Torices,Caroline E. Nunes-Xavier, Rafael Pulido, Juan Carlos Arango-Lasprilla, and Jesus M. Cortes. Brain Circuit Alterations and Cognitive Disability in Late-Onset Cobalamin D Disorder. J Clinical Medicine 9: 990, 2020 [pdf] Abstract Neuroimaging studies describing brain circuits’ alterations in cobalamin (vitamin B12)-deficient patients are limited and have not been carried out in patients with inborn […]

Changchun He, Huafu Chen, Lucina Q Uddin, Asier Erramuzpe, Paolo Bonifazi, Xiaonan Guo, Jinming Xiao, Heng Chen, Xinyue Huang, Lei Li, Wei Sheng, Wei Liao, Jesus M Cortes, and Xujun Duan. Structure-Function Connectomics Reveals Aberrant Developmental Trajectory Occurring at Preadolescence in the Autistic Brain. Cerebral Cortex 30: 5028–5037, 2020 [pdf] Abstract Accumulating neuroimaging evidence shows that age estimation obtained from brain connectomics reflects the level of brain maturation along with […]

Arrate Sevilla , Celia Morales, Pilar A. Ezkurra, Javier Rasero, Verónica Velasco, Goikoane Cancho-Galan, na Sánchez-Diez, armele Mujika, Cristina Penas, Isabel Smith, Aintzane Asumendi, Jesús M. Cortés, Maria Dolores Boyano, and Santos Alonso. BRAF V600E mutational load as a prognosis biomarker in malignant melanoma. Plos One 15:e0230136, 2020 [pdf] Abtstract Analyzing the mutational load of driver mutations in melanoma could provide valuable information regarding its progression. We aimed at analyzing […]

Yossi Mosbacher, Farad Khoyratee, Miri Goldin, Sivan Kanner, Yenehaetra Malakai, Moises Silva, Filippo Grassia, Yoav Ben Simon, Jesus Cortes, Ari Barzilai, Timothée Levi, and Paolo Bonifazi. Toward neuroprosthetic real-time communication from in silico to biological neuronal network via patterned optogenetic stimulation. Scientific Reports 10: 7512, 2020 [pdf] Abstract Restoration of the communication between brain circuitry is a crucial step in the recovery of brain damage induced by traumatic injuries or […]

Filippo Mancuso, Sergio Lage, Javier Rasero, José Luis Díaz‐Ramón, Aintzane Apraiz, Gorka Pérez‐Yarza, Pilar Ariadna Ezkurra, Cristina Penas, Ana Sánchez‐Diez, María Dolores García‐Vazquez, Jesús Gardeazabal, Rosa Izu, Karmele Mujika, Jesús Cortés, Aintzane Asumendi, and María Dolores Boyano. Serum markers improve current prediction of metastasis development in early‐stage melanoma patients: a machine learning‐based study. Molecular Oncology 14:1705-1718, 2020 [pdf] Abstract Metastasis development represents an important threat for melanoma patients, even when […]

Antonio Jimenez-Marin, Diego Rivera, Victoria Boado, Ibai Diez, Fermin Labayen, Irati Garrido, Daniela Ramos-Usuga, Itziar Benito-Sanchez, Javier Rasero, Alberto Cabrera Zubizarreta, Inigo Gabilondo, Sebastiano Stramaglia, Juan Carlos Arango-Lasprilla, Jesus M. Cortes. Brain Connectivity And Cognitive Functioning In Individuals Six Months After Multiorgan Failure Neuroimage: Clinical 25: 102137, 2020 [pdf] Abstract Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder […]

Caroline E. Nunes-Xavier, Olaia Aurtenetxe, Laura Zaldumbide, Ricardo López-Almaraz, Asier Erramuzpe, Jesús M. Cortés, José I. López and Rafael Pulido. Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma Diagnostic Pathology 14:134, 2019 [pdf] Abstract Background: Protein tyrosine phosphatases (PTPs) regulate neuronal differentiation and survival, but their expression patterns and functions in human neuroblastoma (NB) are scarcely known. Here, we have investigated the function […]

Ildefonso M. De la Fuente, Carlos Bringas, Iker Malaina, Benjamin Regner, Alberto Pérez-Samartín, María Dolores Boyano, María Fedetz, José I. López, Gorka Pérez-Yarza, Jesus M. Cortes and Terrence Sejnowski. The nucleus does not significantly affect the migratory trajectories of amoeba in two-dimensional environments Scientific Reports 9:16369, 2019 [pdf] Abstract For a wide range of cells, from bacteria to mammals, locomotion movements are a crucial systemic behavior for cellular life. Despite […]

Garazi Labayru, Ibai Diez, Jorge Sepulcre, Esther Fernández, Miren Zulaica, Jesús M. Cortés, Adolfo López de Munain, Andone Sistiaga. Regional brain atrophy in gray and white matter is associated with cognitiveimpairment in Myotonic Dystrophy type 1 Neuroimage: Clinical 24: 102078, 2019 [pdf] Abstract Background Myotonic Dystrophy type 1 (DM1) is a slowly progressive myopathy characterized by varying multisystemic involvement. Several cerebral features such as brain atrophy, ventricular enlargement, and white […]

Peter beim Graben, Antonio Jimenez-Marin, Ibai Diez, Jesus M. Cortes, Mathieu Desroches and Serafim Rodrigues. Metastable Resting State Brain Dynamics. Frontiers in Computational Neuroscience 13:62, 2019 [pdf] Abstract Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state from where it might […]

Cristina Sanchez-Puelles, Maria Calleja-Felipe, Alberto Ouro, Ghassen Bougamra, Ana Arroyo, Ibai Diez, Asier Erramuzpe, Jesus Cortes, Jose Martinez-Hernandez, Rafael Lujn, Marta Navarrete, Cesar Venero, Andrew Chan, Miguel Morales, Jose A. Esteban and Shira Knafo. PTEN activity defines an axis for plasticity at cortico-amygdala synapses and determines social behavior. Cerebral Cortex 30:505-524, 2019 [pdf] Abstract Phosphatase and tensin homolog on chromosome 10 (PTEN) is a tumor suppressor and autism-associated gene that […]

Ane Murueta-Goyena , Roco del Pino, Paula Reyero , Marta Galds, Begoa Arana, Olaia Lucas Jimenez, Marian Acera, Beatriz Tijero, Naroa Ibarretxe-Bilbao, Natalia Ojeda, Javier Pea, Jesus Cortes, Juan Carlos Gomez-Esteban, Iñigo Gabilondo. Parafoveal thinning of inner retina is associated with visual dysfunction in Lewy body diseases.  Movement disorders 34:1315-1324, 2019 [pdf] Abstract Background: Retinal optical coherence tomography findings in Lewy body diseases and their implications for visual outcomes remain controversial. […]

Jose I. Lopez, Rafael Pulido, Jesus M. Cortes , Javier C. Angulo, and Charles H. Lawrie. Potential impact of PD-L1 (SP-142) immunohistochemical heterogeneity in clear cell renal cell carcinoma immunotherapy.  Pathol Res Pract 214:1110-1114, 2018 [pdf] Abstract Intratumor heterogeneity (ITH) detection remains a challenge in modern oncology because it can have a direct impact on the success of new therapies. Anti-PD-1/PD-L1 immunotherapy is an emerging treatment modality that is showing great promise for […]