Jose Luis Diaz-Ramón,Jesus Gardeazabal, Rosa Maria Izu, Estibaliz Garrote, Javier Rasero,Aintzane Apraiz,Cristina Penas,Sandra Seijo,Cristina Lopez-Saratxaga,Pedro Maria De la Peña,Ana Sanchez-Diaz,Goikoane Cancho-Galan, Veronica Velasco, Arrate Sevilla, David Fernandez, Iciar Cuenca,Jesus María Cortes, Santos Alonso, Aintzane Asumendi, and María Dolores Boyano. Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients. Cancers 2023, 15(7), 2174. [pdf] Abstract: This study set out to assess […]

Javier Rasero, Antonio Jimenez-Marin, Ibai Diez, Roberto Toro, Mazahir T Hasan, Jesus M Cortes. The neurogenetics of functional connectivity alterations in Autism: Insights from subtyping in 657 patients. Biol Psychiatry 2023, S0006-3223(23)01230-1. [pdf] Abstract: Background: There is little consensus and controversial evidence on anatomical alterations in the brain of patients with autism spectrum disorder (ASD), due in part to the large heterogeneity present in ASD, which in turn is a […]

Soraya Martín-Suárez, Jesus M, Cortes, and Paolo Bonifazi. Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state. Brain 2023 [pdf] Abstract: Epilepsy, the condition of recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world’s most prominent neurological disabilities. Seizures which are an expression of neuronal network dysfunction occur in a positive feedback loop of concomitant factors, including also neuro-inflammatory […]

Borja Camino-Pontes, Francisco Gonzalez-Lopez, Gonzalo Santamaría-Gomez, Antonio Javier Sutil-Jimenez, Carolina Sastre-Barrios, Iñigo Fernandez de Pierola, and Jesus M. Cortes. One-year prediction of cognitive decline following cognitive-stimulation from real-world data. Journal of Neuropsychology 2023 [pdf] Abstract: Clinical evidence based on real-world data (RWD) is accumulating exponentially providing larger sample sizes available, which demand novel methods to deal with the enhanced heterogeneity of the data. Here, we used RWD to assess the […]

Antonio Jimenez-Marin, Jolien Gooijers, Nele De Bruyn, Alberto Llera, Geert Verheyden, Stephan P. Swinnen, and Jesus M. Cortes. Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients. Scientific Reports 12: 22400, 2022 [pdf] Beyond the characteristics of a brain lesion, such as its etiology, size or location, lesion network mapping (LNM) has shown that similar symptoms after a lesion reflects similar dis-connectivity patterns, thereby linking […]

Endika Martinez-Gutierrez, Antonio Jimenez-Marin, Sebastiano Stramaglia and Jesus M. Cortes. The structure of anticorrelated networks in the human brain.  Frontiers in Network Physiology, 2022 [pdf] During the performance of a specific task–or at rest–, the activity of different brain regions shares statistical dependencies that reflect functional connections. While these relationships have been studied intensely for positively correlated networks, considerably less attention has been paid to negatively correlated networks, a. k.a. […]

Marilyn Gatica, Fernando E. Rosas, Pedro A. M. Mediano, Ibai Diez, Stephan P. Swinnen, Patricio Orio, Rodrigo Cofre, Jesus M. Cortes. High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model.  PLoS Comput Biol 18(9): e1010431. [pdf] The human brain generates a rich repertoire of spatio-temporal activity patterns, which support a wide variety of motor and cognitive functions. These patterns of activity change with age […]

Martin Iniguez, Antonio Jimenez-Marin, Asier Erramuzpe, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocio Del Pino, Tamara Fernandez, Mar Carmona‑Abellan, Alberto Cabrera-Zubizarreta, Juan Carlos Gómez‑Esteban, Jesus M. Cortes and Inigo Gabilondo. Heart-brain synchronization breakdown in Parkinson’s disease.  npj Parkinson’s Disease (2022) 64 [pdf] Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed […]

Izaro Fernandez-Iriondo, Antonio Jimenez-Marín, Basilio Sierra, Naiara Aginako, Paolo Bonifazi, and Jesus M. Cortes. Brain mapping of behavioral domains using multi-scale networks and canonical correlation analysis. Front. Neurosci. 2022.  article: [pdf] Abstract Simultaneous mapping of multiple behavioral domains into brain networks remains a major challenge. Here, we shed some light on this problem by employing a combination of machine learning, structural and functional brain networks at different spatial resolutions (also […]