JCR Articles

Francesca Santucci, Antonio Jimenez-Marin, Andrea Gabrielli, Paolo Bonifazi, Miguel Ibáñez-Berganza, Tommaso Gili, and Jesus M. Cortes.Partial correlation as a tool for mapping functional-structural correspondence in human brain connectivity. Network Neuroscience 2025. [pdf] Abstract: Brain structure-function coupling has been studied in health and disease by many different researchers in recent years. Most of the studies have estimated functional connectivity matrices as correlation coefficients between different brain areas, despite well-known disadvantages compared […]

Clara Inesta, Beatriz Bonete-Lopez, Javier Oltra-Cucarella, Borja Camino-Pontes, Jesus M. Cortes, Juan Carlos Arango-Lasprilla, Esther Sitges-Macia. Does engagement in cognitive activities contribute to the preservation of brain structure and connectivity in older adults?. Journal of the Neurological Sciences 477: 123658, 2025 [pdf] Abstract Aging is associated with changes in brain structure and connectivity and decrements in certain cognitive abilities. The benefits of active lifestyles in the aging brain and cognition […]

Geraldine Rodríguez-Nieto, Caroline Seer, Hamed Zivari Adab, Antonio Jiménez-Marín, Sima Chalavi, Amirhossein Rasooli, Jesus M. Cortes, Stefan Sunaert, Stephan P. Swinnen. Efficiency of Structural Brain Networks Mediates Age-Associated Differences in Executive Functioning in Older Adults. Frontiers in Aging Neuroscience, 2025. [pdf] Abstract Older age is associated with alterations in executive functioning (EF). Age-related alterations in the integrity of structural brain networks may contribute to EF decline, with potential consequences for […]

Changchun He, Jesus M. Cortes, Yi Ding, Xiaolong Shan, Maoyang Zou, Heng Chen, Huafu Chen, Xianmin Wang, Xujun Duan. Brain Imaging and Behavior, 2025. [pdf] Abstract Accumulating neuroimaging evidence suggests that abnormal functional and structural brain connectivity plays a cardinal role in the pathophysiology of autism spectrum disorder (ASD). Here, we constructed brain networks of functional, structural, and morphological connectivity using data from functional magnetic resonance imaging (fMRI), diffusion tensor […]

Marlis Ontivero-Ortega, Luca Faes, Jesus M. Cortes, Daniele Marinazzo, and Sebastiano Stramaglia. Assessing high-order effects in feature importance via predictability decomposition. Physical Review 111: L033301, 2025. [pdf] Abstract Building on recent advances in describing redundancy and synergy in multivariate interactions among random variables, we propose an approach to quantify cooperative effects in feature importance, a key technique in explainable artificial intelligence. Specifically, we introduce an adaptive version of the widely […]

Asier Erramuzpe, Ane Murueta-Goyena, Antonio Jimenez-Marin, Marian Acera, Sara Teijeira-Portas, Rocío Del Pino, Tamara Fernández-Valle, Ibai Diez, Unai Sainz-Lugarezaresti, Naroa Ibarretxe-Bilbao, Unai Ayala, Maitane Barrenechea, Alberto Cabrera-Zubizarreta, Jesús Cortés, Juan Carlos Gómez-Esteban, Iñigo Gabilondo. Amygdala Neurodegeneration: A Key Driver of VisualDysfunction in Parkinson’s Disease. Ann Clin Transl Neurol 12: 768-779, 2025. [pdf] Abstract Objective: Visual disability in Parkinson’s disease (PD) is not fully explained by retinal neurodegeneration. We aimed to […]

Jorge Garcia Condado, Iñigo Tellaetxe-Elorriaga, Jesus M. Cortes, and Asier Erramuzpe. AgeML: Age Modeling With Machine Learning. IEEE Journal of Biomedical and Health Informatics: 29, 3772-3781, 2025. [pdf] Abstract An approach to age modeling involves the supervised prediction of age using machine learning from subject features. The derived age metrics are used to study the relationship between healthy and pathological aging in multiple body systems, as well as the interactions […]

Joana Garmendia, Garazi Labayru, Antonio Jiménez-Marín, Jorge Villanúa, Jesús Cortés, Adolfo López de Munain and Andone Sistiaga. Hyperconnectivity in resting-state fMRI as a marker of disease severity in Myotonic Dystrophy Type 1. J Neuromuscul Dis 2025; 12: 90–101. [pdf] Abstract Introduction: Myotonic dystrophy type 1 (DM1) patients show both structural and functional brain alterations, including abnormal resting-state (RS) functional connectivity. Although some studies have investigated RS functional connectivity in DM1, […]

Sebastiano Stramaglia, Luca Faes, Jesus M. Cortes, and Daniele Marinazzo. Disentangling high-order effects in the transfer entropy. Phys Rev Res 6, L032007 (2024). [pdf] Abstract Transfer entropy (TE), the primary method for determining directed information flow within a network system, can exhibit bias—either in deficiency or excess—during both pairwise and conditioned calculations, owing to high-order dependencies among the dynamic processes under consideration and the remaining processes in the system used […]

Ildefonso M. De la Fuente, Jose Carrasco-Pujante, Borja Camino-Pontes, Maria Fedetze, Carlos Bringas, Alberto Pérez-Samartín, Gorka Pérez-Yarza, José I. López, Iker Malaina, and Jesus M. Cortes. Systemic cellular migration: The forces driving the directed locomotion movement of cells. PNAS nexus. In press, 2024. [pdf] Abstract Directional motility is an essential property of cells. Despite its enormous relevance in many fundamental physiological and pathological processes, how cells control their locomotion movements […]

Antonio Jimenez-Marin, Ibai Diez, Asier Erramuzpe, Sebastiano Stramaglia, Paolo Bonifazi, and Jesus M. Cortes. Open datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brain. Scientific Data. In press, 2024. [pdf] Abstract The human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connections is critical to advancing our […]

D Ramos-Usuga, A Jimenez-Marin, A Cabrera Zubizarreta, I Benito-Sanchez, D Rivera, E Martinez-Gutierrez, E Panera, V Boado, Fermin Labayen, J M Cortes, Juan C. Arango-Lasprilla. Cognitive and brain connectivity trajectories at one-year post intensive care unit discharge in individuals with COVID-19. Neurorehabilitation. In press, 2024. [pdf] Abstract BACKGROUND: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with […]

Jose Luis Diaz-Ramón,Jesus Gardeazabal, Rosa Maria Izu, Estibaliz Garrote, Javier Rasero,Aintzane Apraiz,Cristina Penas,Sandra Seijo,Cristina Lopez-Saratxaga,Pedro Maria De la Peña,Ana Sanchez-Diaz,Goikoane Cancho-Galan, Veronica Velasco, Arrate Sevilla, David Fernandez, Iciar Cuenca,Jesus María Cortes, Santos Alonso, Aintzane Asumendi, and María Dolores Boyano. Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients. Cancers 2023, 15(7), 2174. [pdf] Abstract: This study set out to assess […]

Javier Rasero, Antonio Jimenez-Marin, Ibai Diez, Roberto Toro, Mazahir T Hasan, Jesus M Cortes. The neurogenetics of functional connectivity alterations in Autism: Insights from subtyping in 657 patients. Biol Psychiatry 2023, S0006-3223(23)01230-1. [pdf] Abstract: Background: There is little consensus and controversial evidence on anatomical alterations in the brain of patients with autism spectrum disorder (ASD), due in part to the large heterogeneity present in ASD, which in turn is a […]

Soraya Martín-Suárez, Jesus M, Cortes, and Paolo Bonifazi. Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state. Brain 2023 [pdf] Abstract: Epilepsy, the condition of recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world’s most prominent neurological disabilities. Seizures which are an expression of neuronal network dysfunction occur in a positive feedback loop of concomitant factors, including also neuro-inflammatory […]

Borja Camino-Pontes, Francisco Gonzalez-Lopez, Gonzalo Santamaría-Gomez, Antonio Javier Sutil-Jimenez, Carolina Sastre-Barrios, Iñigo Fernandez de Pierola, and Jesus M. Cortes. One-year prediction of cognitive decline following cognitive-stimulation from real-world data. Journal of Neuropsychology 2023 [pdf] Abstract: Clinical evidence based on real-world data (RWD) is accumulating exponentially providing larger sample sizes available, which demand novel methods to deal with the enhanced heterogeneity of the data. Here, we used RWD to assess the […]

Antonio Jimenez-Marin, Jolien Gooijers, Nele De Bruyn, Alberto Llera, Geert Verheyden, Stephan P. Swinnen, and Jesus M. Cortes. Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients. Scientific Reports 12: 22400, 2022 [pdf] Beyond the characteristics of a brain lesion, such as its etiology, size or location, lesion network mapping (LNM) has shown that similar symptoms after a lesion reflects similar dis-connectivity patterns, thereby linking […]

Endika Martinez-Gutierrez, Antonio Jimenez-Marin, Sebastiano Stramaglia and Jesus M. Cortes. The structure of anticorrelated networks in the human brain.  Frontiers in Network Physiology, 2022 [pdf] During the performance of a specific task–or at rest–, the activity of different brain regions shares statistical dependencies that reflect functional connections. While these relationships have been studied intensely for positively correlated networks, considerably less attention has been paid to negatively correlated networks, a. k.a. […]

Marilyn Gatica, Fernando E. Rosas, Pedro A. M. Mediano, Ibai Diez, Stephan P. Swinnen, Patricio Orio, Rodrigo Cofre, Jesus M. Cortes. High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model.  PLoS Comput Biol 18(9): e1010431. [pdf] The human brain generates a rich repertoire of spatio-temporal activity patterns, which support a wide variety of motor and cognitive functions. These patterns of activity change with age […]

Martin Iniguez, Antonio Jimenez-Marin, Asier Erramuzpe, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocio Del Pino, Tamara Fernandez, Mar Carmona‑Abellan, Alberto Cabrera-Zubizarreta, Juan Carlos Gómez‑Esteban, Jesus M. Cortes and Inigo Gabilondo. Heart-brain synchronization breakdown in Parkinson’s disease.  npj Parkinson’s Disease (2022) 64 [pdf] Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson’s disease (PD) but their relationship with central autonomic network (CAN) activity is not fully understood. We analyzed […]

Izaro Fernandez-Iriondo, Antonio Jimenez-Marín, Basilio Sierra, Naiara Aginako, Paolo Bonifazi, and Jesus M. Cortes. Brain mapping of behavioral domains using multi-scale networks and canonical correlation analysis. Front. Neurosci. 2022.  article: [pdf] Abstract Simultaneous mapping of multiple behavioral domains into brain networks remains a major challenge. Here, we shed some light on this problem by employing a combination of machine learning, structural and functional brain networks at different spatial resolutions (also […]

Garazi Labayru, Borja Camino, Antonio Jimenez‑Marin, JoanaGarmendia , JorgeVillanua , Miren Zulaica, Jesus M. Cortes, Adolfo López de Munain & Andone Sistiaga. Scientific Reports 12:3988, 2022  article: [pdf] Abstract Myotonic Dystrophy Type 1 (DM1) is a multisystemic disease that afects gray and white matter (WM) tissues. WM changes in DM1 include increased hyperintensities and altered tract integrity distributed in a widespread manner. However, the precise temporal and spatial progression of […]

Maider Nuñez-Ibero, Borja Camino-Pontes, Ibai Diez, Asier Erramuzpe, Endika Martinez-Gutierrez, Sebastiano Stramaglia, Javier O. Alvarez-Cienfuegos, and Jesus M. Cortes. A Controlled Thermoalgesic Stimulation Device for Exploring Novel Pain Perception Biomarkers. IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS 25: 2948-2957, 2021. biorxiv: [pdf] article: [pdf] Abstract Objective: To develop a new device for identifying physiological markers of pain perception by reading the brain’s electrical activity and hemodynamic interactions while applying thermoalgesic […]

Antonio Jimenez-Marin, Ibai Diez, Maria C. Caballero, Isidro Ferrer, Garazi Labayru, Pol Andres-Benito, Andone Sistiaga, Jorge Sepulcre, Adolfo Lopez de Munain, and Jesus M. Cortes. Transcriptional signatures of synaptic vesicle genes define myotonic dystrophy type I neurodegeneration. Neuropathology and Applied Neurobiology . In press, 2021. biorxiv: [pdf] article: [pdf] Abstract Aim: To delineate the neurogenetic profiles of brain degeneration patterns in myotonic dystrophy type I (DM1). Methods: In two cohorts […]

Changchun He, Heng Chen, Xiaonan Guo, Ruishi Wang, Lingyin Kong, Xinyue Huang, Huafu Chen, Jinming Xiao, Xiaolong Shan, Rui Feng, Xujun Duan. Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder. Human Brain Mapping. In press, 2021 [pdf] Abstract Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. […]

Leire Torices, Javier de las Heras, Juan Carlos Arango-Lasprilla, Jesús M. Cortes, Caroline E. Nunes-Xavier , Rafael Pulido. MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution. Molecular Genetics and Metabolism Reports. In press, 2021 [pdf] Abstract Mutations in the MMADHC gene cause cobalamin D disorder (cblD), an autosomal recessive inborn disease with defects in intracellular cobalamin (cbl, vitamin B12) metabolism. CblD patients […]

Sandra Luna, Leire Torices, Janire Mingo, Laura Amo, Isabel Rodríguez‐Escudero, Pablo Ruiz‐Ibarlucea, Asier Erramuzpe, Jesús M. Cortés, María I. Tejada, María Molina, Caroline E. Nunes‐Xavier, José I. López, Víctor J. Cid, and Rafael Pulido. A global analysis of the reconstitution of PTEN function by translational readthrough of PTEN pathogenic premature termination codons. Human Mutation. In press, 2021 [pdf] Abstract The PTEN tumor suppressor gene is mutated with high incidence in […]

Marilyn Gatica, Rodrigo Cofré, Pedro A.M. Mediano, Fernando E. Rosas, Patricio Orio, Ibai Diez, Stephan P. Swinnen, and Jesus M. Cortes. High-order interdependencies in the aging brain. Brain connectivity . In press, 2021. biorxiv: [pdf] article: [pdf] Abstract Background: Brain interdependencies can be studied from either a structural/anatomical perspective (“structural connectivity”-SC) or by considering statistical interdependencies (“functional connectivity”-FC). Interestingly, while SC is by definition pairwise (white-matter fibers project from one […]