Bran Connectivity & Machine Learning

Visual dysfunction is associated with cognitive impairment in Parkinson’s disease

Rocío Del Pino, Marian Acera, Ane Murueta-Goyena, Olaia Lucas-Jimenez, Natalia Ojeda, Naroa Ibarretxe-Bilbao, Javier Pena, Paula Reyero, Jesus M Cortes, Beatriz Tijero, Marta Galdos, Juan Carlos Gomez-Esteban, Inigo Gabilondo. Visual dysfunction is associated with cognitive impairment in Parkinson’s disease. Parkinsonism and Related Disorders 92: 22–25, 2021. article: [pdf]

Abstract
Introduction: Visual dysfunction and cognitive impairment are common in Parkinson’s disease (PD) but the precise contribution of lower-level visual impairment to visual-input based cognitive performance has not been extensively characterized in PD. Methods: We included 49 PD patients and 22 healthy controls (HC). Lower-level visual function tests [high and low contrast visual acuity (HCVA and LCVA) and contrast sensitivity (CS)] and a neuropsychological battery (involving visual cognition) were performed. Pairwise correlations between lower-level visual functions and visual cognition were computed and stepwise linear regressions were fitted introducing age, Geriatric Depression Scale, and lower-level visual functions in the model to calculate their predicted effect on visual cognition. Results: Compared to controls, patients presented a significant impairment in all cognitive domains (visual attention, visual processing speed and visual perception, visuospatial abilities, visuoconstructive abilities, and visual memory), and lower-level visual functions. HCVA and LCVA were significantly associated with visual cognition in PD. HCVA explained up to 49.3% and 34.2% of the variability in visual perception and visuospatial abilities, respectively, whereas LCVA was mainly associated with short- and long-term visual memory and visuospatial abilities. Conclusion: Lower-level visual dysfunction is highly associated with cognitive performance in PD, when cognitive tests are based on visual input. Our results support that lower-level visual functions should be considered when assessing cognitive status of PD patients and might be useful for predicting cognitive deterioration.

This website uses its own cookies for its proper functioning and better user experience. By navigating this website and/or clicking the Accept button, you agree to the use of these technologies and the processing of your data for these purposes. More information    Privacy policy
Privacidad