Publications

A Erramuzpe, JM Encinas, A Sierra, M Maletic-Savatic, AL Brewster, AE Anderson, S Stramaglia and JM M Cortes. Variations in whole-brain functional connectivity across seizure chronification in a mouse model of mesial temporal lobe epilepsy. Society for Neuroscience Annual Meeting 2014. How does the brain become epileptic? Although this is a major question for modern Neurology, we do not have yet a proper answer. Despite of intense research in the […]

I. Ortega-Martinez, J. Gardeazabal, A. Erramuzpe, R. Fernandez-Suarez, E. Alonso-Tejerina, G. Perez-Yarza, J.M. Cortes, I.M. de la Fuente, A. Asumendi and M.D. Boyano. Serum Proteomics in Melanoma Biomarker Discovery. 13th Annual World Congress of the Human Proteome Organization 2014. Introduction and objectives Patients with early-stage melanoma and no lymph node involvement have a high likelihood of cure after complete excision of the tumor by surgery. However, there is no effective […]

J.M. Cortes, J. Goñi, M.A. Muñoz and D.R. Chialvo. Generic dynamics at criticality links brain structure to function. Frontiers in Neuroinformatics, 2013 [pdf] The relation, influence, and constraints between structure and function of the human brain is not yet well understood, even for the widely studied resting state. In the last decade, different topological descriptors, and dynamical models such as neural mass or more complicated coupling models have shown how […]

V. Maki-Marttunen, J.M. Cortes, M. Villareal and D.R. Chialvo. Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness. Computational NeuroScience (CNS) 2013 Meeting. BMC Neuroscience 2013, 14(Suppl 1):P83 [pdf] CNS 2013 Best Student Poster Award Winner. Recent studies suggest that the functional organization of brain networks is altered in patients with severe disorders of consciousness (DOC), including coma [1]. A better characterization of these […]

J.M. Cortes, D. Marinazzo, P. Series, M.W. Oram, T.J. Sejnowski and M.C.W. van Rossum. Neural adaptation reduces energy cost while preserving coding accuracy. Society for Neuroscience Annual Meeting 2010 Neurons in the primary visual cortex initially respond vigorously when a preferred stimulus is presented, but typically adapt as stimulation continues. The functional consequences of adaptation are unclear. Typically a reduction of firing reduces single neuron accuracy, but it has been […]

J.M. Cortes, D. Marinazzo, P. Tudela and E. Madrid. Causal connectivity analysis of tracking faces in presence of repeated distractors during working memory tasks. Society for Neuroscience Annual Meeting 2009 Recognition of a specific visual target among equally familiar distracters requires neural mechanisms for tracking items in working memory. High Density EEG recordings were obtained from sixteen right-handed normal participants while they performed a visual working memory task in which […]

L. Mancera, R. Jimenez-Galan, J.M. Cortes. Visual Information Processing trough a simulated retina: Linear vs Bayesian reconstruction of natural movies. Society for Neuroscience Annual Meeting 2009 In vision neuroscience much of the knowledge about information processing comes from experiments in presence of highly reduced stimuli: orientated bars, drifting gratings or dots and sometimes combinations of them. Very often, the implicit linearity of the stimuli works quite well to explain linear […]

J.M. Cortes, D. Marinazzo, P. Series, M. Oram, T.J. Sejnowski and M.C.W. van Rossum. Heterogeneous adaptation effects on visual population coding efficiency. COSYNE 2008: 5th Computational and Systems Neuroscience Meeting The cellular and synaptic mechanisms underlying visual adaptation have extensively been debated during the last years (for reviews see Kohn 2007 and Schwartz 2007). However, the effect of neural adaptation on information coding is difficult to study experimentally as it […]

J.M. Cortes, T.J. Sejnowski and M.C.W. van Rossum. Reverse Engineering: Weight dynamics consistent with experimental weight distributions. Society for Neuroscience Annual Meeting 2007 The strengths of synaptic connections that are responsible for perception and memory change on time scales ranging from milliseconds to many days. A key question is how memories can be made stable over long periods of time despite the ongoing synaptic plasticity. The distribution of synaptic weights […]

D. Marinazzo, J.M. Cortes, M. Postlethwaite and M. Hennig. Synaptic depression and multi-scale phenomena. Society for Neuroscience Annual Meeting 2007 How short term plasticity (STP) affects synaptic transmission has been widely studied during the last decade (Zucker and Regehr, 2001). During repetitive stimulation, a postsynaptic response can be facilitated or depressed or shaped by a combination of both. These effects have been successfully explained by models focusing on two main […]

J.M.A.M. Kusters, A.P.R. Theuvenet, D.L. Ypey, W.P.M. van Meerwijk, J.M. Cortes and C.C.A.M. Gielen. Calcium Oscillations driving an excitable membrane: Hysteresis and Bi-stability. Biophysical Society: 51th Annual Meeting. Biophysical Journal 257A-257A Suppl. S, 2007 In normal rat kidney (NRK) fibroblasts the excitable membrane exhibits action potentials caused by an intracellular, IP3-mediated calcium oscillation (CaO). We modeled that process in detail and applied bifurcation analysis to investigate the dynamic behaviour of […]