A privilege to work with such wonderful people, from left to right, Asier Erramuzpe, Paolo Bonifazi, Jesus Cortes, Beatriz Mateos, Ibai Diez, Iñaki Escudero and Javier Rasero.
Yearly Archives: 2016
2016, Brain connectivity methods in humans and their application to different pathologies. Andes University. Bogota, Colombia
2016, Connectivity and Disconnectivity after Traumatic Brain Injury. Invited talk. Sexto Congreso Internacional de Neuropsicologia Intrahospitalaria. Bogota, Colombia
2016, Brain connectivity methods in humans and their application to different pathologies. University of Antioquia. Medellin, Colombia
My collaboration with Dr. JI Lopez on a new method for tumor sampling called Multi-Site Tumor Sampling went to the so prestigious journal The Pathologist Here, you can download the pdf Here, you can visit the website
From the interaction between different people with common interests and ambitions, we have created and are participating in the neurokafe. More information at https://neurokafe.github.io/
Ibai Diez, David Drijkoningen, Sebastiano Stragmalia, Paolo Bonifazi, Daniele Marinazzo, Jolien Gooijers, Stephan P. Swinnen, Jesus M. Cortes. Enhanced pre-frontal functional-structural networks to support postural control deficits after traumatic brain injury in a pediatric population. Network Neuroscience 1: 116-142, 2017 [pdf] Preprint at [pdf] Traumatic brain injury (TBI) affects the structural connectivity, triggering the re-organization of structural-functional circuits in a manner that remains poorly understood. We focus here on brain […]
J Mingo, A Erramuzpe, S Luna, I Diez, JM Cortes and R Pulido. One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections. PLoS One 11: e0160972, 2016 [pdf] Site-directed mutagenesis (SDM) is a powerful tool to create defined collections of protein variants for experimental and clinical purposes, but effectiveness is compromised when a large number of mutations is required. We present here a one-tube-only standardized SDM […]
Lopez JI and Cortes JM. A multi-site cutting device implements efficiently the divide-and-conquer strategy in tumor sampling. F1000Research 5:1587, 2016 [pdf] We recently showed that in order to detect intra-tumor heterogeneity a Divide-and-Conquer (DAC) strategy of tumor sampling outperforms current routine protocols. This paper is a continuation of this work, but here we focus on DAC implementation in the Pathology Laboratory. In particular, we describe a new simple method that […]
Guarch R, Cortes JM, Lawrie CH and Lopez JI. Multi-site tumor sampling (MSTS) improves the performance of histological detection of intratumor heterogeneity in clear cell renal cell carcinoma (CCRCC). F1000Research 5: 2020, 2016 [pdf] Current standard-of-care tumor sampling protocols for CCRCC (and other cancers) are not efficient at detecting intratumoural heterogeneity (ITH). We have demonstrated that an alternative protocol, multi-site tumor in silico sampling (MSTS) based upon the divide and […]
2016, A novel brain partition highlights the modular skeleton shared by structure and function. BIFI, Zaragoza, Spain
Vitronectin and Dermcidin serum levels predict the metastatic progression of AJCC I-II early stage melanoma. Idoia Ortega-Martínez, Jesús Gardeazabal, Asier Erramuzpe, Ana Sanchez-Diez,Jesús M Cortés, María D. García-Vázquez, Gorka Pérez-Yarza, Rosa Izu, Jose Luís Díaz-Ramón, Ildefonso M. de la Fuente, Aintzane Asumendi and María D. Boyano. Int J Cancer 139:1598-607, 2016 [pdf] Like many cancers, an early diagnosis of melanoma is fundamental to ensure a good prognosis, although an important […]
S. Stramaglia, L. Angelini, G. Wu, J.M. Cortes, L. Faes and D. Marinazzo. Synergetic and redundant information flow detected by unnormalized Granger causality: application to resting state fMRI. IEEE Trans Biomed Eng 63: 2518 – 2524, 2016 [pdf] Abstract—Objectives We develop a framework for the analysis of synergy and redundancy in the pattern of information flow between subsystems of a complex network. Methods The presence of redundancy and/or synergy in […]
A divide-and-conquer strategy in tumor sampling enhances detection of intratumor heterogeneity in routine pathology: A modeling approach in clear cell renal cell carcinoma. JI Lopez and JM Cortes. F1000Research 5:385, 2016 [pdf] Intratumor heterogeneity (ITH) is an inherent process in cancer development which follows for most of the cases a branched pattern of evolution, with different cell clones evolving independently in space and time across different areas of the same […]
Ibai Diez, David Drijkoningen, Sebastiano Stramaglia, Paolo Bonifazi, Daniele Marinazzo, Stephan P. Swinnen*, Jesus M. Cortes* (* Equal last-author contribution). Prefrontal brain connectivity re-organization after traumatic axonal injury. 22nd Annual Meeting of the Organization for Human Brain Mapping, OHBM 2016 [pdf] Background. Traumatic axonal injury damages brain structural connectivity which is later compensated by a re-organization in structural-functional circuits in a form which remains inadequately characterized. Methods. We enrolled N=14 […]
I Diez, P Bonifazi, I Escudero, B Mateos, MA Munoz, S Stramaglia, and JM Cortes. The Brain Hierarchical Atlas. 22nd Annual Meeting of the Organization for Human Brain Mapping , OHBM 2016 [pdf] Background. Most used brain atlases are purely anatomical or structural [1-4], and others are purely functional, like the well-known Brodmann atlas based on lesion studies or data-driven methods [5-6]. Although obtaining suitable brain partitions (or atlases) has […]
2016, Metodos de conectividad a gran escala para conectar funcion cerebral con su estructura. Foundation CITA-Alzheimer. San Sebastian, Spain
2016, Aportes de la neuroimagen computacional en el diagnostico y seguimiento de los gliomas. As a part of the Neuro-oncology course in the MSc in Neurosciences. University of the Basque Country, Spain
López JI, Errarte P, Erramuzpe A, Guarch R, Cortés JM, Angulo JC, Pulido R, Irazusta J, Llarena R, Larrinaga G. Fibroblast activation protein predicts prognosis in clear cell renal cell carcinoma. Hum Pathol. 54:100-105, 2016 [pdf] Clear cell renal cell carcinoma is a complex disease with only partial response to therapy and scarce reliable clinical parameters indicative of progression and survival. Fibroblast activation protein expression has been correlated with prognosis […]
L.Zaldumbide, A. Erramuzpe, R. Guarch, R.l Pulido, J.M. Cortes and J.I. Lopez. Snail heterogeneity in clear cell renal cell carcinoma. BMC Cancer 16:194, 2016 [pdf] Background: Intratumor heterogeneity may be responsible of the unpredictable aggressive clinical behavior that some clear cell renal cell carcinomas display. This clinical uncertainty may be caused by insufficient sampling, leaving out of histological analysis foci of high grade tumor areas. Although molecular approaches are providing […]
S. Rodrigues, M. Desroches, M. Krupa, J.M. Cortes, T.J. Sejnowski and A.B. Ali. Time-coded neurotransmitter release at excitatory and inhibitory synapses. Proc Natl Acad Sci USA 113:E1108-15, 2016 [pdf] Communication between neurons at chemical synapses is regulated by hundreds of different proteins that control the release of neurotransmitter that is packaged in vesicles, transported to an active zone, and released when an input spike occurs. Neurotransmitter can also be released […]
Julia M. Kroos, Ibai Diez, Jesus M. Cortes, Sebastiano Stramaglia and Luca Gerardo Giorda. Geometry shapes propagation: assessing the presence and absence of cortical symmetries through a computational model of cortical spreading depression. Frontiers in Computational Neuroscience 10:6, 2016 [pdf] Cortical spreading depression (CSD), a depolarization wave which originates in the visual cortex and travels towards the frontal lobe, has been suggested to be one neural correlate of aura migraine. […]