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Jesus M. Cortes

Neuroscience, Brain connectivity and Machine Learning
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Jesus M. Cortes

Neuroscience, Brain connectivity and Machine Learning
  • Search
  • Home
  • Biosketch
  • Latest News
  • Talks
  • Publications
    • JCR Articles
    • non JCRs
    • Abstracts
  • Teaching

Veronica Maki-Marttunen*, Ibai Diez*, Jesus M. Cortes, Dante R. Chialvo and Mirta Villarreal (*Equal contribution). Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder of consciousness. Frontiers in Neuroinformatics 7:24, 2013 [pdf] Severe traumatic brain injury can lead to disorders of consciousness (DOC) characterized by deficit in conscious awareness and cognitive impairment including coma, vegetative state, minimally consciousness, and lock-in syndrome. Of crucial importance is to […]

JCR Articles Publications

Disruption of transfer entropy and inter-hemispheric brain functional connectivity in patients with disorder …

Published November 11, 2015

Jesus M Cortes*, Mathieu Desroches*, Serafim Rodrigues*, Romain Veltz , Miguel A. Muñoz and Terrence J. Sejnowski (* Equal Contribution). Short-term synaptic plasticity in the deterministic Tsodyks-Markram model leads to unpredictable network dynamics. Proc Natl Acad Sci USA 110:16610-16615, 2013 [pdf] Short-term synaptic plasticity strongly affects the neural dynamics of cortical networks. The Tsodyks and Markram (TM) model for short-term synaptic plasticity accurately accounts for a wide range of physiological […]

JCR Articles Publications

Short-term synaptic plasticity in the deterministic Tsodyks-Markram model leads to unpredictable network dynamics

Published November 11, 2015

D. Marinazzo, M. Pellicoro, Guo-Rong Wu, L. Angelini, J.M. Cortes and S. Stramaglia. Information Transfer and Criticality in the Ising Model on the Human Connectome. PLoS One 9: e93616, 2014 [pdf] We implement the Ising model on a structural connectivity matrix describing the brain at two different resolutions. Tuning the model temperature to its critical value, i.e. at the susceptibility peak, we find a maximal amount of total information transfer […]

JCR Articles Publications

The Ising model on a brain network maximizes Information Transfer at criticality

Published November 11, 2015

Ildefonso M. de la Fuente, Jesus M. Cortes, David A. Pelta, Juan Veguillas. Attractor Metabolic Networks. PLoS One 8: e58284, 2013 [pdf] Background The experimental observations and numerical studies with dissipative metabolic networks have shown that cellular enzymatic activity self-organizes spontaneously leading to the emergence of a Systemic Metabolic Structure in the cell, characterized by a set of different enzymatic reactions always locked into active states (metabolic core) while the […]

JCR Articles Publications

Attractor Metabolic Networks

Published November 11, 2015

J.M. Cortes, A. Lopez, R. Molina and A.K. Katsaggelos. Variational Bayesian localization of EEG sources with generalized Gaussian priors. EPJ-Plus 127: 140, 2012 [pdf] Front cover [pdf] Although in the last decades the use of Magnetic Resonance Imaging has grown in popularity as a tool for the structural analysis of the brain, including MRI, fMRI and recently DTI, the ElectroEncephaloGraphy (EEG) is still-today an interesting technique for the understanding of […]

JCR Articles Publications

Variational Bayesian localization of EEG sources with generalized Gaussian priors

Published November 11, 2015

Jorge Hidalgo, Luis F Seoane, Jesus M Cortes and Miguel A Munoz. Stochastic amplification of fluctuations in cortical up-states. PLoS ONE 7: e40710, 2012 [pdf] Cortical neurons are bistable; as a consequence their local field potentials can fluctuate between quiescent and active states, generating slow 0.5-2 Hz oscillations which are widely known as transitions between Up and Down States. Despite a large number of studies on Up-Down transitions, deciphering its […]

JCR Articles Publications

Stochastic amplification of fluctuations in cortical up-states

Published November 11, 2015

Ildefonso M. De la Fuente, Jesus M. Cortes, Martin-Blas Perez-Pinilla, Vicente Ruiz-Rodriguez and Juan Veguillas. The metabolic core and catalytic switches are fundamental elements in the self-regulation of the Systemic Metabolic Structure of Cells. PLoS ONE 6:e27224, 2011 [pdf] Background. Experimental observations and numerical studies with dissipative metabolic networks have shown that cellular enzymatic activity self-organizes spontaneously leading to the emergence of a metabolic core formed by a set of […]

JCR Articles Publications

The metabolic core and catalytic switches are fundamental elements in the self-regulation of …

Published November 11, 2015

Ildefonso M. De la Fuente and Jesus M. Cortes. Quantitative analysis of the effective inter-enzyme connectivity in glycolysis. PLoS ONE 7:e30162, 2012 [pdf] Yeast glycolysis is considered the prototype of dissipative biochemical oscillator. In cellular conditions, under sinusoidal source of glucose, the activity of enzymes can display either periodic, quasi-periodic or chaotic behavior. By means of a system of non-linear differential equations with delay we have obtained different time series […]

JCR Articles Publications

Quantitative analysis of the effective inter-enzyme connectivity in glycolysis

Published November 11, 2015

J. M. Cortes, D. Marinazzo, P. Series, M.W. Oram, T.J. Sejnowski and M.C.W. van Rossum. The effect of neural adaptation on population coding accuracy. Journal of Computational Neuroscience 32:387-402, 2012 [pdf] Most neurons in the primary visual cortex initially respond vigorously when a preferred stimulus is presented, but adapt as stimulation continues. The functional consequences of adaptation are unclear. Typically a reduction of firing rate would reduce single neuron accuracy […]

JCR Articles Publications

The effect of neural adaptation on population coding accuracy

Published November 11, 2015

J.M. Cortes, A. Greve, A. Barrett and M.C.W. van Rossum. Dynamics and Robustness of Familiarity Memory. Neural Computation 22: 448-466, 2010 [pdf] When presented with an item or a face, one might have a sense of recognition without the ability to recall when or where the stimulus has been encountered before. This sense of recognition is called familiarity memory. Following previous computational studies of familiarity memory, we investigate the dynamical […]

JCR Articles Publications

Dynamics and Robustness of Familiarity Memory

Published November 11, 2015

J.J. Torres, J. Marro, J.M. Cortes and B. Wemmenhove. Instabilities in attractor networks with fast synaptic fluctuations and partial updating of the neurons activity. Neural Networks 21: 1272-1277, 2008 [pdf] We present and study a probabilistic neural automaton in which the fraction of simultaneously-updated neurons is a parameter, rhoin(0,1). For small rho, there is relaxation towards one of the attractors and a great sensibility to external stimuli and, for rho […]

JCR Articles Publications

Instabilities in attractor networks with fast synaptic fluctuations and partial updating of the …

Published November 11, 2015

J. Marro, J.J. Torres and J.M. Cortes. Complex behavior in a network with time-dependent connections and silent nodes. Journal of Statistical Mechanics P02017, 2008 [pdf] We studied, both analytically and numerically, excitable networks in which connections are time-dependent and some of the nodes remain silent at each time step, and we show that these two features may induce intriguing functional complexity. More specifically, we consider (a) a heterogeneous distribution of […]

JCR Articles Publications

Complex behavior in a network with time-dependent connections and silent nodes

Published November 11, 2015

J.M.A.M. Kusters, J.M. Cortes, W.P.M. van Meerwijk, D.L. Ypey, A.P.R. Theuvenet and C.C.A.M. Gielen. Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing. Physical Review Letters 98: 098107, 2007. Nomination of PRL HighLights in the Magazine The Biological Physicist 7, April 2007 [pdf] Many cells reveal oscillatory behavior. Some cells reveal action-potential firing resulting from Hodgkin-Huxley (HH) type dynamics of ion channels in the cell membrane. […]

JCR Articles Publications

Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing

Published November 3, 2015

J. Marro, J.J. Torres and J.M. Cortes. Networks with Heterogeneously Weighted Connections and Partial Synchronization of Nodes. Computer Physics Communications 177: 180-183, 2007 [pdf] A network of stochastic nodes in which connections are heterogeneously weighted and dynamics may by varied from single-node updating to full synchronization as in familiar cellular automata is studied concerning computational strategies and states of attention in the brain.

JCR Articles Publications

Networks with Heterogeneously Weighted Connections and Partial Synchronization of Nodes

Published November 3, 2015

J.J. Torres, J. M. Cortes, J. Marro and H.J. Kappen. Attractor Neural Networks with Activity-Dependent Synapses: The Role of Synaptic Facilitation. Neurocomputing 70: 2022-2025, 2007 [pdf] We studied an autoassociative neural network with dynamic synapses which include a facilitating mechanism. We have developed a general mean-field framework to study the relevance of the different parameters defining the dynamics of the synapses and their influence on the collective properties of the […]

JCR Articles Publications

Attractor Neural Networks with Activity-Dependent Synapses: The role of synaptic facilitation

Published November 3, 2015

J. Marro, J.J. Torres and J.M. Cortes. Chaotic hopping between attractors in neural automata. Neural Networks 20: 230-235, 2007 [pdf] We present a neurobiologically-inspired stochastic cellular automaton whose state jumps with time between the attractors corresponding to a series of stored patterns. The jumping varies from regular to chaotic as the model parameters are modified. The resulting irregular behavior, which mimics the state of attention in which a system shows […]

JCR Articles Publications

Chaotic hopping between attractors in neural automata

Published November 3, 2015

J.J. Torres, J.M. Cortes, J. Marro and H.J. Kappen. Competition between synaptic depression and facilitation in attractor neural networks. Neural Computation 19: 2739-2755, 2007 [pdf] We study the effect of competition between short-term synaptic depression and facilitation on the dynamic properties of attractor neural networks, using Monte Carlo simulation and a mean-field analysis. Depending on the balance of depression, facilitation, and the underlying noise, the network displays different behaviors, including […]

JCR Articles Publications

Competition between synaptic depression and facilitation in attractor neural networks

Published November 3, 2015

J. M. Cortes, J. Marro and J. J. Torres. Control of neural chaos by synaptic noise. Biosystems 87: 186-190, 2007 [pdf] We study neural automata or neurobiologically inspired cellular automata which exhibits chaotic itinerancy among the different stored patterns or memories. This is a consequence of activity-dependent synaptic fluctuations, which continuously destabilize the attractor and induce irregular hopping to other possible attractors. The nature of these irregularities depends on the […]

JCR Articles Publications

Control of neural chaos by synaptic noise

Published November 3, 2015

J. M. Cortes, J. J. Torres, J. Marro, P. L. Garrido and H. J. Kappen. Effects of fast presynaptic noise in attractor neural networks. Neural Computation 18: 614-633, 2006 [pdf] We study both analytically and numerically the effect of presynaptic noise on the transmission of information in attractor neural networks. The noise occurs on a very short timescale compared to that for the neuron dynamics and it produces short-time synaptic […]

JCR Articles Publications

Effects of fast presynaptic noise in attractor neural networks

Published November 3, 2015

J. J. Torres, J. Marro, P. L. Garrido, J. M. Cortes, F. Ramos and M. A. Munoz. Effects of static and dynamic disorder on the performance of neural automata. Biophysical Chemistry 115: 285-288, 2005 [pdf] We report on both analytical and numerical results concerning stochastic Hopfield-like neural automata exhibiting the following (biologically inspired) features: (1) Neurons and synapses evolve in time as in contact with respective baths at different temperatures; […]

JCR Articles Publications

Effects of static and dynamic disorder on the performance of neural automata

Published November 3, 2015

Sebastiano Stramaglia, Leonardo Angelini, Jesus M. Cortes and Daniele Marinazzo. Synergy, redundancy and unnormalized Granger causality. EMBS 4037-4040, 2015 [arXiv:1504.03584] [pdf]

non JCRs Publications

Synergy, redundancy and unnormalized Granger causality

Published October 26, 2015

S. Stramaglia, J.M. Cortes, L. Angelini, M. Pellicoro and D. Marinazzo. Information flow in Ising models on brain networks. V.M. Mladenov and P.C. Ivanov (Eds.): NDES 2014, CCIS 438, pp. 301–308, 2014 [pdf]. We analyze the information flow in the Ising model on two real networks, describing the brain at the mesoscale, with Glauber dynamics. We find that the critical state is characterized by the maximal amount of information flow […]

non JCRs Publications

Information flow in Ising models on brain networks

Published October 26, 2015

J. Hidalgo, L.F. Seoane, J.M. Cortes and M.A. Muñoz. Does the phenomenon of stochastic amplification of fluctuations play a relevant role in cortical dynamics? AIP Conference Proceedings 1510: 94-100, 2012 [pdf] We review the mechanism of stochastic amplification of fluctuations in the context of fast cortical oscillations observed during up-states both in vitro and in vivo. For this purpose, we employ minimalistic models based on short-time synaptic depression with or […]

non JCRs Publications

Does the phenomenon of stochastic amplification of fluctuations play a relevant role in …

Published October 26, 2015

A. Lopez, J.M. Cortes, D. Lopez-Oller, R. Molina and A.K. Katsaggelos. Hyperparameters Estimation for the Bayesian Localization of the EEG Sources with TV Priors. EUSIPCO 2012: 20th European Signal Processing Conference , pags 489-493, 2012 [pdf] In this work we propose a new Bayesian method for the non-invasive localization of EEG sources. For this problem, most of the existing methods assume that the sources are distributed throughout the brain volume […]

non JCRs Publications

Hyperparameters Estimation for the Bayesian Localization of the EEG Sources with TV Priors

Published October 26, 2015

J.M. Cortes, D. Marinazzo, T.J. Sejnowski and M.C.W. van Rossum. The Direction of Tilt Aftereffects Depends on Short-term Inhibitory Facilitation. NIPS 2011, Submitted but Rejected [pdf] Neural adaptation leads to changes in the responses of single neurons and neural populations during continued exposure to a stimulus. At the single neuron level, adaptation reduces responses to a constant stimulus. At the perceptual level, adaptation can manifest itself as aftereffects. For instance, […]

non JCRs Publications

The Direction of Tilt Aftereffects Depends on Short-term Inhibitory Facilitation

Published October 26, 2015

J.M. Cortes. Interfaces cerebro-maquina, un gran paso hacia la Inteligencia Artificial. Ciencia Cognitiva: Revista Electronica de Divulgacion 3: 24-26, 2009 [pdf] Dentro de la Neurociencia Computacional, la Neuro-ingeniería desarrolla sistemas de comunicación entre una máquina y alguna parte del sistema nervioso. Sin lugar a dudas, estos sistemas constituyen un gran reto científico, ingenieril y ético. Sin embargo, su correcto funcionamiento todavía plantea muchos problemas.

non JCRs Publications

Interfaces cerebro-maquina, un gran paso hacia la Inteligencia Artificial

Published October 26, 2015

J.M. Cortes. La Neurociencia Computacional hoy: I. Que es y por que es dificil su estudio. Ciencia Cognitiva: Revista Electronica de Divulgacion 3: 5-7, 2009 [pdf] La Neurociencia Computacional es una disciplina consolidada, con más de 20 años de desarrollo, y que emplea técnicas muy diversas para entender diferentes computaciones cerebrales. Aquí se introduce brevemente mediante dos artículos. En el primero, “Qué es y por qué es difícil su estudio”, […]

non JCRs Publications

La Neurociencia Computacional hoy: I. Que es y por que es dificil su …

Published October 26, 2015

J.M. Cortes. La Neurociencia Computacional hoy: II. Un ejemplo muy representativo en el campo. Ciencia Cognitiva: Revista Electronica de Divulgacion 3: 8-11, 2009 [pdf] La Neurociencia Computacional es un campo reciente, pero bien establecido dentro de las Neurociencias. En un primer artículo Cortes 2009, “Qué es y por qué es difícil su estudio”, explico su principal paradigma: todo proceso mental que tiene lugar en nuestro cerebro tiene un circuito o […]

non JCRs Publications

La Neurociencia Computacional hoy: II. Un ejemplo muy representativo en el campo.

Published October 26, 2015

J.M.A.M. Kusters, J.M. Cortes, W.P.M. van Meerwijk, D.L.Ypey, A.P.R. Theuvenet and C.C.A.M. Gielen. Oscillatory activity in cells: multi-stability and hysteresis. AIP Conference Proceedings 887: 40-50, 2007 [pdf] Oscillatory activity of cells has been the topic of many studies. Oscillatory activity can be due to action potential firing corresponding to the well-known Hodgkin-Huxley (HH) type dynamics of ion-channels in the cell membrane or due to IP3-mediated calcium oscillations in the endoplasmic […]

non JCRs Publications

Oscillatory activity in cells: multi-stability and hysteresis

Published October 26, 2015

J.J. Torres, J. M. Cortes and J. Marro. Information processing with unstable memories. AIP Conference Proceedings 887: 115-128, 2007 [pdf] We present a theoretical framework which allows one to study both theoretically and numerically the effect of including activity dependent mechanisms in the dynamics of synapses in simple neural networks. In particular, we study synaptic changes at different time scales from less than the millisecond (fast synaptic noise) to the […]

non JCRs Publications

Information processing with unstable memories

Published October 26, 2015

[spanish]

Jesus M. Cortes, Physicist, Data Scientist:

  • More than 20 years experience - In research, working in data science, including modeling, analyses, and image processing, see my ORCID profile at https://orcid.org/0000-0002-9059-8194
  • High interdisciplinary experience - Combining physics, neuroscience, neuroimaging, data science, engineering, and medicine.
  • Getting funding - In competitive calls and working with the industry, achieving funding for more than 9,14 Millions Euros.
  • Science communication - Giving more than 119 talks at the international level, and publishing 129 articles indexed in Journal Citation Reports, 100 of them in the first quartile.
  • Training of qualified professionals - Supervising more than 40 students, including Bachelor, Master, and Thesis.
  • Research projects evaluation - Regularly for different funding agencies such as Spanish National Science and Health Ministry, and also at international programs, such as the Marie Sklodowska-Curie Actions, the Israel Science Foundation, the Research Foundation Flanders (FWO), the EPSRC in the UK, and the BBSRC in the UK.

Contact - If you are interested in knowing details or possibilities of collaboration:
Jesus M. Cortes, Ph.D.:
jesus.m.cortes@gmail.com
Computational Neuroimaging Lab
BioBizkaia Health Research Institute
Hospital Universitario Cruces
Plaza de Cruces, s/n E-48903. Barakaldo, Spain
Tel +34 94 600 6000 (ext. 5199)


 

Jesus M. Cortes, Físico, Científico de Datos:

  • Más de 20 años de experiencia - En investigación, trabajando con datos, en modelado, análisis e imágenes. Consulte mi perfil profesional ORCID en https://orcid.org/0000-0002-9059-8194
  • Altamente interdisciplinar - Combinando física, neurociencias, neuroimagen, ciencia de datos, ingeniería y medicina.
  • Consiguiendo financiación - En convocatorias competitivas y trabajando con la industria, habiendo conseguido más de 9,14 Millones de Euros.
  • Difusión internacional - Impartiendo más de 119 charlas a nivel internacional y publicando más 129 artículos indexados en el Journal Citation Reports, 100 de ellos en primer cuartil.
  • Formación de personal cualificado - Supervisando a más de 40 estudiantes, incluyendo Licenciatura, Maestría y Tesis.
  • Evaluación de proyectos - Lo hago de forma habitual en el Plan Nacional de Ciencia y Salud Español, y en programas internacionales, incluidas las acciones Marie Sklodowska-Curie, la Israel Science Foundation, la Research Foundation Flanders (FWO), EPSRC en Reino Unido y BBSRC en Reino Unido.
  • Contacta - Si estás interesado en conocer detalles o posibilidades de colaboración:

Jesus M. Cortes, Ph.D.:
jesus.m.cortes@gmail.com
Computational Neuroimaging Lab
BioBizkaia Health Research Institute
Hospital Universitario Cruces
Plaza de Cruces, s/n E-48903. Barakaldo, Spain
Tel +34 94 600 6000 (ext. 5199)

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