Claudia Aponte, Antonio Jimenez-Marín, Malen Razkin, John Fredy Ochoa Gómez, Asier Erramuzpe, Ibai Diez, David Aguillón-Niño, Carlos Tobón, Jesús M. Cortés. Subregional Functional Connectivity of the Precuneus as a Preclinical Biomarker in Alzheimer’s Disease. Neurology Research International, 7281786, 2026 [pdf]
Abstract
Introduction: The precuneus(Pc)isacentralhubintegratingdiversebrainfunctions,anditisearlyinvolvedinAlzheimer’s
disease (AD)pathophysiology,yetitssubregionalvulnerabilityremainspoorlyunderstood.Thisstudyaimstodelineatethe
diBerential involvementandvulnerabilityofthesesubdivisionsintheearlystagesofAD.
Methods: We conductedaresting-stateFCanalysisofPcsubregionsin32cognitivelyunimpairedcarriersofthePSEN1E280A
mutation comparedto25noncarriersusingseed-basedanalyses.
Results: As comparedtononcarriers,wefoundthatthegroupofasymptoticcarriershadincreasedconnectivityfromthe7Am
subregion towardtheentorhinalcortex,superiortemporalgyrus,insula-operculum,dlPFC,andsomatosensoryareas.Moreover,
the POS2subregionsigniFcantlydecreasedconnectivitywiththeanteriorinsulaanddlPFC.HigherMoCAscorescorrelatedwith
increased connectivitywithinandbetweenthePcandfrontoparietalnetworks.
Discussion: These resultsrevealdistinctpatternsofearlyfunctionalreorganizationandsupportthesubregionalPcanalysisin
identifying sensitivebiomarkersforpreclinicalAD,oftenoverlookedinconventionalwhole-regionanalyses.